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Am J Physiol Heart Circ Physiol (December 12, 2002). doi:10.1152/ajpheart.00315.2002
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Articles in PresS, published online ahead of print December 12, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00315.2002
Submitted on April 8, 2002
Accepted on October 23, 2002

Inhibition of Vascular ATP-Sensitive Potassium Channels Does Not Affect Reactive Hyperemia In The Human Forearm

H. M. Omar Farouque* and Ian T. Meredith

* To whom correspondence should be addressed. E-mail: omar.farouque{at}med.monash.edu.au.

The extent to which KATP channels contribute to reactive hyperemia in humans is unresolved. We examined the role of KATP channels in regulating reactive hyperemia induced by 5 minutes of forearm ischemia. Thirty-one healthy subjects had forearm blood flow measured with venous occlusion plethysmography. Reactive hyperemia could be reproducibly induced (n=9). The contribution of vascular KATP channels to reactive hyperemia was determined by measuring forearm blood flow before and during brachial artery infusion of glibenclamide, a KATP channel inhibitor (n=12). To document KATP channel inhibition with glibenclamide, co-infusion with diazoxide, a KATP channel opener, was undertaken (n=10). Glibenclamide did not significantly alter resting forearm blood flow or the initial and sustained phases of reactive hyperemia. However, glibenclamide attenuated the hyperemic response induced by diazoxide. These data suggest that KATP channels do not play an important role in controlling forearm reactive hyperemia and that other mechanisms are active in this adaptive response.




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