| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
2 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Medical College of Wisonsin and the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
3 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
4 Department of Physiology, Louisiana State University, New Orleans, LA, USA
5 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: cknapp{at}mcw.edu.
Recent evidence suggests that reactive oxygen species (ROS) promote proliferation and migration of vascular smooth muscle (VSMC) and endothelial cells (EC). We tested the hypothesis that ROS serve as crucial messengers during coronary collateral development. Dogs were subjected to brief (2 min), repetitive coronary artery occlusions (1/hr; 8/day; 21 day duration) in the absence (Occlusion, n=8) or presence of N-acetylcysteine (Occlusion + NAC, n=8). A sham group (Sham, n=8) was instrumented identically but received no occlusions. In separate experiments, ROS generation after a single 2 min coronary artery occlusion was assessed with dihydroethidium fluorescence. Coronary collateral blood flow (expressed as a percentage of normal zone flow) was significantly increased (71±7%) in occlusion dogs after 21 days but remained unchanged (13±3%) in sham dogs. Treatment with NAC attenuated increases in collateral blood flow (28±8%). Brief coronary artery occlusion and reperfusion caused ROS production (256±33% of baseline values) that was abolished with NAC (104±12%). Myocardial interstitial fluid (MIF) produced tube formation and proliferation of VSMC and EC in occlusion but not in NAC-treated or sham dogs. The results indicate that ROS are critical for the development of the coronary collateral circulation.
This article has been cited by other articles:
|
|
 |
|
  R. Reed, B. Potter, E. Smith, R. Jadhav, P. Villalta, H. Jo, and P. Rocic Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1811 - H1821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Reed, C. Kolz, B. Potter, and P. Rocic The Mechanistic Basis for the Disparate Effects of Angiotensin II on Coronary Collateral Growth Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 61 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rocic, C. Kolz, R. Reed, B. Potter, and W. M. Chilian Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2729 - H2736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Angermayr, M. Fernandez, M. Mejias, J. Gracia-Sancho, J. C. Garcia-Pagan, and J. Bosch NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats Gut, April 1, 2007; 56(4): 560 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ushio-Fukai Redox signaling in angiogenesis: Role of NADPH oxidase Cardiovasc Res, July 15, 2006; 71(2): 226 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chalothorn, H. Zhang, J. A. Clayton, S. A. Thomas, and J. E. Faber Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H947 - H959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tojo, M. Ushio-Fukai, M. Yamaoka-Tojo, S. Ikeda, N. Patrushev, and R. W. Alexander Role of gp91phox (Nox2)-Containing NAD(P)H Oxidase in Angiogenesis in Response to Hindlimb Ischemia Circulation, May 10, 2005; 111(18): 2347 - 2355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Li and A. M Shah Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1014 - R1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kin, Z.-Q. Zhao, H.-Y. Sun, N.-P. Wang, J. S. Corvera, M. E. Halkos, F. Kerendi, R. A. Guyton, and J. Vinten-Johansen Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion Cardiovasc Res, April 1, 2004; 62(1): 74 - 85. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
