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Am J Physiol Heart Circ Physiol (September 26, 2002). doi:10.1152/ajpheart.00319.2002
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Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00319.2002
Submitted on April 10, 2002
Accepted on September 17, 2002

Input-size dependence of the baroreflex neural arc transfer characteristics

Toru Kawada1*, Yusuke Yanagiya1, Kazunori Uemura1, Tadayoshi Miyamoto1, Can Zheng1, Meihua Li1, Masaru Sugimachi1, and Kenji Sunagawa1

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita-shi, Osaka, Japan

* To whom correspondence should be addressed. E-mail: torukawa{at}res.ncvc.go.jp.

Static characteristics of the baroreflex neural arc from pressure input to sympathetic nerve activity (SNA) show sigmoidal nonlinearity, whereas its dynamic characteristics approximate a derivative filter where the magnitude of SNA response becomes greater as the input frequency increases. To reconcile the static nonlinear and dynamic linear components, we examined the effects of input amplitude on the apparent linear transfer function of the neural arc. In 9 anesthetized rabbits, we perturbed isolated carotid sinus pressure using binary white noise while varying the input amplitude among 5, 10, 20, and 40 mmHg. With increasing input amplitude, the transfer gain at 0.01 Hz decreased from 1.21±0.27 to 0.49±0.28 (P<0.01). Moreover, the slope of the transfer gain between 0.03 and 0.3 Hz decreased from 14.3±3.7 to 6.5±2.5 dB/decade (P<0.01). We conclude that the model consisting of a sigmoidal component following rather than preceding a derivative component explains the observed results and thus can be used as a first approximation of the overall neural arc transfer characteristics.




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