|
|
||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00319.2002
Submitted on April 10, 2002
Accepted on September 17, 2002
1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita-shi, Osaka, Japan
* To whom correspondence should be addressed. E-mail: torukawa{at}res.ncvc.go.jp.
Static characteristics of the baroreflex neural arc from pressure input to sympathetic nerve activity (SNA) show sigmoidal nonlinearity, whereas its dynamic characteristics approximate a derivative filter where the magnitude of SNA response becomes greater as the input frequency increases. To reconcile the static nonlinear and dynamic linear components, we examined the effects of input amplitude on the apparent linear transfer function of the neural arc. In 9 anesthetized rabbits, we perturbed isolated carotid sinus pressure using binary white noise while varying the input amplitude among 5, 10, 20, and 40 mmHg. With increasing input amplitude, the transfer gain at 0.01 Hz decreased from 1.21±0.27 to 0.49±0.28 (P<0.01). Moreover, the slope of the transfer gain between 0.03 and 0.3 Hz decreased from 14.3±3.7 to 6.5±2.5 dB/decade (P<0.01). We conclude that the model consisting of a sigmoidal component following rather than preceding a derivative component explains the observed results and thus can be used as a first approximation of the overall neural arc transfer characteristics.
This article has been cited by other articles:
![]() |
K. Yamamoto, T. Kawada, A. Kamiya, H. Takaki, T. Shishido, K. Sunagawa, and M. Sugimachi Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1081 - H1089. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Emonnot, C. Bakhos, B. Chapuis, V. Orea, C. Barres, and C. Julien Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R736 - R741. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Julien The enigma of Mayer waves: Facts and models Cardiovasc Res, April 1, 2006; 70(1): 12 - 21. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Kamiya, T. Kawada, K. Yamamoto, D. Michikami, H. Ariumi, K. Uemura, C. Zheng, S. Shimizu, T. Aiba, T. Miyamoto, et al. Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits J. Physiol., July 1, 2005; 566(1): 237 - 246. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Burattini, P. Borgdorff, and N. Westerhof The baroreflex is counteracted by autoregulation, thereby preventing circulatory instability Exp Physiol, July 1, 2004; 89(4): 397 - 405. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kawada, T. Miyamoto, K. Uemura, K. Kashihara, A. Kamiya, M. Sugimachi, and K. Sunagawa Effects of neuronal norepinephrine uptake blockade on baroreflex neural and peripheral arc transfer characteristics Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1110 - R1120. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kawada, K. Uemura, K. Kashihara, A. Kamiya, M. Sugimachi, and K. Sunagawa A derivative-sigmoidal model reproduces operating point-dependent baroreflex neural arc transfer characteristics Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2272 - H2279. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kashihara, T. Kawada, Y. Yanagiya, K. Uemura, M. Inagaki, H. Takaki, M. Sugimachi, and K. Sunagawa Bezold-Jarisch reflex attenuates dynamic gain of baroreflex neural arc Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H833 - H840. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kawada, K. Uemura, K. Kashihara, Y. Jin, M. Li, C. Zheng, M. Sugimachi, and K. Sunagawa Uniformity in dynamic baroreflex regulation of left and right cardiac sympathetic nerve activities Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1506 - R1512. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |