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Am J Physiol Heart Circ Physiol (September 27, 2001). doi:10.1152/ajpheart.00330.2001
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Articles in PresS, published online ahead of print September 27, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00330.2001
Submitted on April 24, 2001
Accepted on September 17, 2001

Endothelium-Dependent Arterial Wall Tone-Elasticity modulated by Blood Viscosity

Edmundo I Cabrera Fischer1*, Ricardo L Armentano2, Franco M Pessana2, Sebastian Graf2, Luis E Romero2, Alejandra I Christen2, Alain Simon3, and Jaime Levenson3

1 Basic Sciences Research Institute, Favaloro University, Buenos Aires, Argentina; CONICET, Buenos Aires, Argentina
2 Basic Sciences Research Institute, Favaloro University, Buenos Aires, Argentina
3 Centre de Medecine Preventive Cardiovasculaire, Broussais Hopital, Paris, France

* To whom correspondence should be addressed. E-mail: fischer{at}favaloro.edu.ar.

The role of blood viscosity on arterial wall elasticity before and after de-endothelization (DE) was studied. Seven ovine brachiocephalic arteries were studied in-vitro under physiological pulsatile flow conditions achieved by a mock circulation loop. Instantaneous pressure and diameter signals were assessed in each arterial segment. Incremental elastic moudulus (Einc) was calculated using the slope of the pure elastic stress-strain relationship. There was no significant difference between Einc values before and after DE (3.11 vs. 3.16 107dyn/cm2) at a blood viscosity of 2.00 mPa.s. Increases in blood viscosity (2.50, 3.00; 3.50 and 4.00 MPa.s always resulted in decreases of Einc before DE; inversely, increases in blood viscosity resulted in increases of Einc after DE. These values of Einc, for identical levels of blood viscosity, were always significantly lower (p<0.05) before DE than those obtained after DE. Arterial wall elasticity assessed through Einc was strongly influenced by blood viscosity, probably due to presence or absence of endothelium relaxing factors, or to direct shear smooth muscle activation when endothelial cells are removed.




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