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1 Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: jlombard{at}mcw.edu.
Sprague-Dawley rats were fed either a high-salt (HS) diet (4.0% NaCl) or a low-salt (LS) diet (0.4% NaCl) for 3 days. NO and superoxide production were assessed in the thoracic aorta by evaluating the fluorescence signal intensity from DAF-2 DA and dihydroethidine, respectively. Methacholine caused increased NO release in aortas from rats on LS, but not HS diet. The SOD mimetic tempol restored methacholine-induced NO release in aortas from rats on HS diet. Methacholine also caused superoxide production in aortas of rats on HS diet, but not in aortas of rats on LS diet. Tempol and L-NMMA eliminated methacholine-induced superoxide production in aortas from rats on HS diet. Aortic rings from rats on HS diet showed impaired methacholine-induced relaxation, which was improved by tempol. Tempol alone caused a NO dependent relaxation of norepinephrine-precontracted aortas that was significantly greater in aortas of rats on HS diet than in vessels from rats on LS diet. These data suggest that HS diet impairs endothelium-dependent relaxation via reduced NO levels and increased superoxide production.
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