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Am J Physiol Heart Circ Physiol (August 1, 2002). doi:10.1152/ajpheart.00338.2002
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Articles in PresS, published online ahead of print August 1, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00338.2002
Submitted on April 15, 2002
Accepted on July 28, 2002

Influence of Gender on the Response to Hemodynamic Overload Following Myocardial Infarction

Mohit Jain1, Ronglih Liao1, Bruno K Podesser1, Soeun Ngoy1, Carl S Apstein1, and Franz R Eberli2*

1 Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, MA, USA
2 Swiss Cardiovascular Center Bern, University Hospital Bern, Bern, Switzerland

* To whom correspondence should be addressed. E-mail: franz.eberli{at}dim.usz.ch.

Objective: Following myocardial infarction (MI), the left ventricle undergoes ventricular remodeling, characterized by progressive global dilation, infarct expansion and compensatory hypertrophy of the non-infarcted myocardium. Little attention has been given to the response of remodeling myocardium to additional hemodynamic overload. Studies have indicated that gender may influence remodeling and the response to both MI and hemodynamic overload. We therefore determined 1) the structural and function consequences of superimposing hemodynamic overload (systemic hypertension) on remodeling myocardium following a MI and 2) the potential influence of gender on this remodeling response. Methods: Male and female Dahl salt-sensitive and salt resistant rats underwent coronary ligation, resulting in similar degrees of MI. One week post-MI, all rats were placed on a high-salt diet. Four groups were then studied four weeks following initiation of high-salt feeding: MI female, MI female + hypertension, MI Male, and MI Male + hypertension. Results: Hypertension-induced pressure overload resulted in additional comparable degrees of myocardial hypertrophy in both females and males. In females, hypertension post-MI resulted in concentric hypertrophy with no additional cavity dilation and no measurable scar thinning. In contrast, in males, hypertension post-MI resulted in eccentric hypertrophy, further LV cavity dilation and scar thinning. Physiologically, concentric hypertrophy in post-MI hypertensive females resulted in elevated contractile function, whereas eccentrically hypertrophied males had no such increase. Conclusion: Female gender influences favorably the remodeling and physiologic response to hemodynamic overload following large myocardial infarction.




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