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Am J Physiol Heart Circ Physiol (June 13, 2002). doi:10.1152/ajpheart.00340.2002
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Articles in PresS, published online ahead of print June 13, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00340.2002
Submitted on April 18, 2002
Accepted on June 10, 2002

Preload-Adjusted Maximal Power of the Right Ventricle: Contribution of the Intercept of the End-Systolic P-V Relation (Vd)

Patrick Segers1*, H. Alex Leather2, Pascal Verdonck1, Yuan-Yuan Sun2, and Patrick F. Wouters2

1 Hydraulics Laboratory - IBITECH, Ghent University, Gent, Belgium
2 Centre for Experimental Surgery and Anaesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium

* To whom correspondence should be addressed. E-mail: patrick.segers{at}rug.ac.be.

In order to assess whether Preload-Adjusted Maximal Power (PAMP), calculated as PWRmax/Vedß (PWRmax: maximal power; Ved: end-diastolic volume) with ß = 2, is an index of right ventricular (RV) contractility, we measured RV pressure (P) and volume (V) and pulmonary artery pressure and flow in 10 dogs at baseline and after inotropic stimulation. PAMP was derived from steady state data, while the slope (Ees) and intercept (Vd) of the end-systolic P-V relation were derived from data obtained during vena caval occlusion. Inotropic stimulation increased Ees (0.96±0.25 to 1.62±0.28 mmHg/ml; P<0.001) and Vd (-3.0±17.2 to 12.4±10.8 ml; P<0.05), but not PAMP (0.24±0.10 to 0.36±0.22 mWatt/ml2; P=0.09). We found a strong relation between the optimal ß-factor for preload-adjustment and Vd. A corrected PAMP (PAMPc = PWRmax/(Ved-Vd)2), incorporating the Vd-dependency, was sensitive to the inotropic changes (0.23±0.12 to 0.54±0.17 mWatt/ml2; P<0.001), with a good correlation with Ees (r = 0.88, P<0.001).




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