The vitamin D₃ and nicotine (VDN) model is one of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of this aging model on normal and diseased hearts by way of myocardial infarction (MI). Wistar rats were treated with VDN (VDN, n=9), subjected to MI by coronary ligation (MI, n=10) or to a combination of both MI and VDN treatment (VDN/MI, n=14). A sham treated group served as control (CTRL, n=10). Trans-thoracic echocardiography was performed every 2 weeks whereas invasive indices were obtained at week 8 before sacrifice. Calcium, collagen and protein contents were measured in the heart and the aorta. Systolic blood pressure, pulse pressure, thoracic aortic calcium and end-systolic elastance as indix of myocardial contractility were the greatest in the aging model compared to MI and CTRL (pVDN of the 2 way ANOVA < 0.05). Left ventricular wall stress and BNP (p_VDNxMI =NS) were the greatest while ejection fraction, stroke volume and cardiac output were the lowest in the combined group versus all other groups (p_VDNxMI < 0.05). The combination of ISH due to this aging model and MI demonstrates significant alterations in cardiac function. This model mimics several clinical phenomena of cardiovascular aging and may thus serve to further study novel therapies.