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1 UPRES 2087, Faculte de medecine, Universite Jules Verne, Amiens, France
2 Research Division, Ochsner Clinic Foundation, New Orleans, LA, USA
3 UPRES2705-APHP, Universite Paris Sud 11, Paris, France
* To whom correspondence should be addressed. E-mail: MSlama0508{at}aol.com.
This study was performed to validate echocardiographic and Doppler techniques for the assessment of left ventricular (LV) diastolic function in spontaneously hypertensive (SHR) and normotensive Wistar rats. In 11 Wistar and 20 SHR rats we compared 51 sets of invasive and Doppler LV diastolic indices. Non invasive indices of LV relaxation were related to -dp/dt min, particularly isovolumic relaxation time (IVRT), Tei index, Em (early velocity of mitral annulus using Doppler tissue imaging), and early mitral flow propagation velocity (Vp) using M-mode color (r = 0.28 to 0.56; p<0.05 to 0.0001). When the role of systolic load was considered, the correlation between Doppler indices of LV diastolic function and the normalized relaxation rate (dp/dtmin/LV systolic pressure) improved (r = 0.48 to 0.86; p = 0.004 to 0.0001, respectively). Similarly, Doppler indices of LV diastolic function and Tau correlated well (r = 0.50 to 0.84; p = 0.0002 to 0.0001, respectively). In addition, 8 SHR and 8 Wistar rats were compared; their LV end-diastolic diameters were similar whereas the SHR LV mass was greater. Furthermore, IVRT and Tei index were significantly higher and, Em was lower in the SHR. Moreover, Tau was higher in SHR demonstrating impaired LV relaxation. In conclusion, LV relaxation can be assessed reliably using echocardiographic and Doppler techniques; and, using these indices, impaired relaxation was demonstrated in the SHR
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