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1 Department of Medicine, Cardiovascular Research Group, Manchester Royal Infirmary, Manchester, United Kingdom
2 BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
* To whom correspondence should be addressed. E-mail: aizzard{at}man.ac.uk.
The aims of the study were to compare the myogenic and structural properties of middle cerebral arteries (MCA) from the stroke-prone spontaneously hypertensive rat (SHRSP) with MCA from the spontaneously hypertensive rat (SHR), before stroke development in SHRSP. Rats were fed a "Japanese" diet (low protein rat chow and 1% NaCl in the drinking water) from 8 wk and cerebral arteries were studied in vitro at 12 wk, using a pressure arteriograph. Systolic pressure was significantly increased in the SHRSP, compared with the SHR at 12 wk. Between 60 and 180 mmHg, MCA from SHR maintained an essentially constant diameter i.e. displayed a "myogenic range", whereas the diameter of MCA from the SHRSP progressively increased as a function of pressure. Passive lumen diameter of MCA from the SHRSP was reduced at high pressure and wall thickness and wall/lumen were increased, compared with the SHR. Wall cross-sectional area was also increased in MCA from SHRSP, compared with the SHR, indicating growth. The stress-strain relationship was shifted to the left in MCA from SHRSP, indicating decreased MCA distensibility, compared with SHR. However, collagen staining with picrosirius red revealed a redistribution of collagen to the outer half of the MCA wall in the SHRSP, compared with the SHR. These data demonstrate impaired myogenic properties in pre-stroke SHRSP, compared with the SHR, which may explain stroke development. The structural differences in MCA from SHRSP, compared with the SHR, were a consequence of both growth and a reduced distensibility.
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