AJP - Heart AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (July 8, 2004). doi:10.1152/ajpheart.00356.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
287/5/H1906    most recent
00356.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tang, T.
Right arrow Articles by Hammond, H. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tang, T.
Right arrow Articles by Hammond, H. K.
Submitted on April 13, 2004
Accepted on June 30, 2004

Adenylyl Cyclase Type VI Corrects Cardiac Sarcoplasmic Reticulum Calcium Uptake Defects in Cardiomyopathy

Tong Tang1, Mei Hua Gao1, David M. Roth2, Tracy Guo1, and H. Kirk Hammond1*

1 Department of Medicine, University of California at San Diego, San Diego, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA
2 VA San Diego Healthcare System, San Diego, CA, USA; Department of Anesthesiology, University of California at San Diego, San Diego, CA, USA

* To whom correspondence should be addressed. E-mail: khammond{at}ucsd.edu.

Calcium malfunction plays a central role in heart failure. Here, we provide evidence that adenylyl cyclase type VI restores SERCA2a affinity for calcium and maximum velocity of cardiac calcium uptake by sarcoplasmic reticulum in murine dilated cardiomyopathy. Restoration of normal SERCA2a affinity for calcium is associated not only with decreased phospholamban protein expression but also with increased phospholamban phosphorylation by PKA activation. The ratio of phosphorylated ryanodine receptor 2 (RyR2) to RyR2 protein was increased, but the amount of phosphorylated RyR2 was unaffected. These data provide a possible mechanism by which adenylyl cyclase type VI - in contrast to other signaling elements associated with increased cAMP generation - has a salutary effect in the failing heart.




This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
N. C. Lai, T. Tang, M. H. Gao, M. Saito, T. Takahashi, D. M. Roth, and H. K. Hammond
Activation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice
J. Am. Coll. Cardiol., April 15, 2008; 51(15): 1490 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. Fischmeister, L. R.V. Castro, A. Abi-Gerges, F. Rochais, J. Jurevicius, J. Leroy, and G. Vandecasteele
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases
Circ. Res., October 13, 2006; 99(8): 816 - 828.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.