AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (October 31, 2002). doi:10.1152/ajpheart.00360.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/H475    most recent
00360.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackson, B. M
Right arrow Articles by Gorman, R. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, B. M
Right arrow Articles by Gorman, R. C

Articles in PresS, published online ahead of print October 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00360.2002
Submitted on May 8, 2002
Accepted on October 7, 2002

Borderzone Geometry Increases Wall Stress After Myocardial Infarction: A Contrast Echocardiographic Assessment

Benjamin M Jackson1*, Joseph H Gorman1, Ivan S Salgo2, Sina L Moainie1, Theodore Plappert3, Martin St. John-Sutton3, L H Edmunds1, and Robert C Gorman1

1 Department of Surgery and the Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
2 Philips Medical Systems, Andover, MA, USA
3 Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

* To whom correspondence should be addressed. E-mail: benjamin.jackson{at}uphs.upenn.edu.

After myocardial infarction (MI), the borderzone expands chronically, causing ventricular dilatation and congestive heart failure (CHF). In an ovine model (n=4) of anteroapical MI that results in CHF, contrast echocardiography was used to image short-axis LV cross sections and identify borderzone myocardium before and after coronary artery ligation. In the borderzone at end systole, the LV endocardial curvature (K) decreased from 0.86±0.33 cm-1at baseline to 0.35±0.19 cm-1 at 1 hr (p<0.05), corresponding to a mean decrease of 55%. Also in the borderzone, the wall thickness (h) decreased from 1.14±0.26 cm at baseline to 1.01±0.25 cm at 1 hr (p<0.05), corresponding to a mean decrease of 11%. By Laplace's law, wall stress is inversely proportional to the product K.h. Therefore, a 55% decrease in K results in a 122% increase in circumferential stress; a 11% decrease in h results in a 12% increase in circumferential stress. These findings indicate that after MI, geometric changes cause increased dynamic wall stress, which likely contributes to borderzone expansion and remodeling.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
J. J. Pilla, J. H. Gorman III, and R. C. Gorman
Theoretic impact of infarct compliance on left ventricular function.
Ann. Thorac. Surg., March 1, 2009; 87(3): 803 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Hamamoto, B. G. Leshnower, L. M. Parish, H. Sakamoto, S. Kanemoto, R. Hinmon, S. Miyamoto, J. H. Gorman III, and R. C. Gorman
Regional Heterogeneity of Myocardial Reperfusion Injury: Effect of Mild Hypothermia
Ann. Thorac. Surg., January 1, 2009; 87(1): 164 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Yu, K. L. Christman, E. Chin, R. E. Sievers, M. Saeed, and R. J. Lee
Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy.
J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): 180 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Feygin, Q. Hu, C. Swingen, and J. Zhang
Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2313 - H2321.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Hung, M. Chaput, J. L. Guerrero, M. D. Handschumacher, L. Papakostas, S. Sullivan, J. Solis, and R. A. Levine
Persistent Reduction of Ischemic Mitral Regurgitation by Papillary Muscle Repositioning: Structural Stabilization of the Papillary Muscle Ventricular Wall Complex
Circulation, September 11, 2007; 116(11_suppl): I-259 - I-263.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Langer, F. Rodriguez, A. Cheng, S. Ortiz, K. B. Harrington, M. K. Zasio, G. T. Daughters, J. C. Criscione, N. B. Ingels, and D. C. Miller
Alterations in Lateral Left Ventricular Wall Transmural Strains During Acute Circumflex and Anterior Descending Coronary Occlusion
Ann. Thorac. Surg., July 1, 2007; 84(1): 51 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q. Hu, X. Wang, J. Lee, A. Mansoor, J. Liu, L. Zeng, C. Swingen, G. Zhang, J. Feygin, K. Ochiai, et al.
Profound bioenergetic abnormalities in peri-infarct myocardial regions
Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H648 - H657.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. M. Jackson, L. M. Parish, J. H. Gorman III, Y. Enomoto, H. Sakamoto, T. Plappert, M. G. St. John Sutton, I. Salgo, and R. C. Gorman
Borderzone Geometry After Acute Myocardial Infarction: A Three-Dimensional Contrast Enhanced Echocardiographic Study
Ann. Thorac. Surg., December 1, 2005; 80(6): 2250 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Ashikaga, S. R. Mickelsen, D. B. Ennis, I. Rodriguez, P. Kellman, H. Wen, and E. R. McVeigh
Electromechanical analysis of infarct border zone in chronic myocardial infarction
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1099 - H1105.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Enomoto, J. H. Gorman III, S. L. Moainie, B. M. Jackson, L. M. Parish, T. Plappert, A. Zeeshan, M. G. St. John-Sutton, and R. C. Gorman
Early Ventricular Restraint After Myocardial Infarction: Extent of the Wrap Determines the Outcome of Remodeling
Ann. Thorac. Surg., March 1, 2005; 79(3): 881 - 887.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y. Enomoto, J. H. Gorman III, S. L. Moainie, T. S. Guy, B. M. Jackson, L. M. Parish, T. Plappert, A. Zeeshan, M. G. St. John-Sutton, and R. C. Gorman
Surgical treatment of ischemic mitral regurgitation might not influence ventricular remodeling
J. Thorac. Cardiovasc. Surg., March 1, 2005; 129(3): 504 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. Jayasankar, L. T. Bish, T. J. Pirolli, M. F. Berry, J. Burdick, and Y. J. Woo
Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function
Ann. Thorac. Surg., June 1, 2004; 77(6): 2122 - 2129.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. M. Jackson, J. H. Gorman III, and R. C. Gorman
Increased border-zone stress in bulging ventricular aneurysm
Ann. Thorac. Surg., May 1, 2004; 77(5): 1876 - 1876.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. S. Guy IV, S. L. Moainie, J. H. Gorman III, B. M. Jackson, T. Plappert, Y. Enomoto, M. G. St. John-Sutton, L. H. Edmunds Jr, and R. C. Gorman
Prevention of ischemic mitral regurgitation does not influence the outcome of remodeling after posterolateral myocardial infarction
J. Am. Coll. Cardiol., February 4, 2004; 43(3): 377 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A.K. Hasnat, E. T. van der Velde, J. K.F. Hon, and M. H. Yacoub
Reproducible model of post-infarction left ventricular dysfunction: haemodynamic characterization by conductance catheter
Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 98 - 104.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.