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Am J Physiol Heart Circ Physiol (December 5, 2002). doi:10.1152/ajpheart.00374.2002
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Articles in PresS, published online ahead of print December 5, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00374.2002
Submitted on May 2, 2002
Accepted on November 26, 2002

TNF{alpha} antibodies are as effective as ischemic preconditioning in reducing infarct size in rabbits

Sergej Belosjorow1, Ines Bolle2, Alexej Duschin1, Gerd Heusch1*, and Rainer Schulz1

1 Institut fur Pathophysiologie, Universitatsklinikums Essen, Essen, -, Germany
2 Zentrales Tierlabor, Universitatsklinikums Essen, Essen, -, Germany

* To whom correspondence should be addressed. E-mail: gerd.heusch{at}uni-essen.de.

Pretreatment with TNF{alpha}-antibodies (TNF{alpha}-Ab) abolishes myocardial infarct size reduction by late ischemic preconditioning (IP). Whether or not TNF{alpha} is also important for myocardial infarct size reduction by classic IP is unknown. Anesthetized rabbits were untreated (G1,n=7), classically preconditioned by 5 min left coronary artery occlusion/10 min reperfusion (G2,n=6) or pretreated with TNF{alpha}-Ab without (G3,n=6) or with IP (G4,n=6) before undergoing 30 min occlusion and 180 min reperfusion. Infarct size in G1 was 44±11 (mean±SD)% of the area at risk. With a comparable area at risk, infarct size was reduced to 13±7%, 23±8% and 19±12 % (all p<0.05) in G2, G3 and G4, respectively. The circulating TNF{alpha} concentration was increased during ischemia in G1 from 752±403 to 1542±482U/ml (p<0.05), but remained unchanged in all other groups. Circulating TNF{alpha} concentration during ischemia and infarct size correlated in all groups (r=0.76). IP, TNF{alpha}-Ab and the combined approach reduced infarct size to a comparable extent. Therefore, the question whether or not TNF{alpha} is causally involved in the infarct size reduction by IP in rabbits could not be answered.




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