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Am J Physiol Heart Circ Physiol (June 13, 2002). doi:10.1152/ajpheart.00375.2002
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Articles in PresS, published online ahead of print June 13, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00375.2002
Submitted on May 6, 2002
Accepted on June 12, 2002

Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia -reperfusion injury

Karine Laude1, Christian Thuillez1, and Vincent Richard1*

1 Pharmacology, INSERM E9920, Rouen, France

* To whom correspondence should be addressed. E-mail: Vincent.Richard{at}univ-rouen.fr.

Experiments were designed to test whether NO and peroxynitrite trigger delayed coronary endothelial protection induced by preconditioning (PC) in rats. Prolonged ischemia reperfusion markedly reduced the response of isolated coronary arteries to acetylcholine, and this was prevented by PC performed 24 hours earlier. The NOS inhibitor L-NAME administered during PC abolished its delayed endothelial protective effect, while the iNOS inhibitor 1400W had no effect. Delayed endothelial PC was also abolished by the peroxynitrite scavengers selenomethionine or uric acid given during PC. In parallel, the NO/peroxynitrite donor SIN-1 and authentic peroxynitrite, administered 24 hours before prolonged ischemia-reperfusion mimicked endothelial PC, whereas the NO donor SNAP had no effect. This suggests that peroxynitrite is an essential trigger of the delayed coronary endothelial protection induced by PC in rat hearts




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 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Laude, J. Favre, C. Thuillez, and V. Richard
NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2053 - H2060.
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