AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (June 13, 2002). doi:10.1152/ajpheart.00375.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/H1418    most recent
00375.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laude, K.
Right arrow Articles by Richard, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laude, K.
Right arrow Articles by Richard, V.

Articles in PresS, published online ahead of print June 13, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00375.2002
Submitted on May 6, 2002
Accepted on June 12, 2002

Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia -reperfusion injury

Karine Laude1, Christian Thuillez1, and Vincent Richard1*

1 Pharmacology, INSERM E9920, Rouen, France

* To whom correspondence should be addressed. E-mail: Vincent.Richard{at}univ-rouen.fr.

Experiments were designed to test whether NO and peroxynitrite trigger delayed coronary endothelial protection induced by preconditioning (PC) in rats. Prolonged ischemia reperfusion markedly reduced the response of isolated coronary arteries to acetylcholine, and this was prevented by PC performed 24 hours earlier. The NOS inhibitor L-NAME administered during PC abolished its delayed endothelial protective effect, while the iNOS inhibitor 1400W had no effect. Delayed endothelial PC was also abolished by the peroxynitrite scavengers selenomethionine or uric acid given during PC. In parallel, the NO/peroxynitrite donor SIN-1 and authentic peroxynitrite, administered 24 hours before prolonged ischemia-reperfusion mimicked endothelial PC, whereas the NO donor SNAP had no effect. This suggests that peroxynitrite is an essential trigger of the delayed coronary endothelial protection induced by PC in rat hearts




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Laude, J. Favre, C. Thuillez, and V. Richard
NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2053 - H2060.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.