| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Integrative Physiology, Univerity of North Texas Health Science Center, Fort Worth, Texas, USA
2 Department of Integrative Physiology, Univerity of North Texas Health Science Center, Fort Worth, Texas, USA; Sleep Consultants of Texas, Fort Worth, Texas, USA
* To whom correspondence should be addressed. E-mail: Michael_Cutler{at}hotmail.com.
Obstructive sleep apnea is associated with sustained elevation of muscle sympathetic nerve activity (MSNA) and altered chemoreflex control of MSNA both of which likely play an important role in the development of hypertension in these patients. Additionally, short-term exposure to intermittent hypoxic apneas can produce sustained elevation of MSNA. Therefore, we tested the hypothesis that 20 min of intermittent hypoxic apneas can alter chemoreflex control of MSNA. Twenty-one subjects were randomly assigned to one of three groups (hypoxic apnea, hypercapnic hypoxia, and isocapnic hypoxia). Subjects were exposed to 30 s of the perturbation every min for 20 min. Chemoreflex control of MSNA was assessed during baseline, 1 min post, and every 15 min throughout 180 min of recovery by the MSNA response to a single hypoxic apnea. Recovery hypoxic apneas were matched to a baseline hypoxic apnea with a similar nadir of SaO2. A significant main effect for chemoreflex control of MSNA was observed following 20 min of intermittent hypoxic apneas (p<0.001). The MSNA response to a single hypoxic apnea was attenuated 1 min post exposure compared to baseline (p<0.001), became augmented within 30 min of recovery and remained augmented through 165 min of recovery (p<0.05). Comparison of treatment groups revealed no differences in the chemoreflex control of MSNA during recovery (p=0.69). These data support the hypothesis that 20 min of intermittent hypoxic apneas can alter chemoreflex control of MSNA. Furthermore, this response appears to be mediated by hypoxia.
This article has been cited by other articles:
|
|
 |
|
  T. V. Serebrovskaya, E. B. Manukhina, M. L. Smith, H. F. Downey, and R. T. Mallet Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension? Experimental Biology and Medicine, June 1, 2008; 233(6): 627 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. A. Leuenberger, C. S. Hogeman, S. Quraishi, L. Linton-Frazier, and K. S. Gray Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans J Appl Physiol, September 1, 2007; 103(3): 835 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Fu, N. E. Townsend, S. M. Shiller, E. R. Martini, K. Okazaki, S. Shibata, M. J. Truijens, F. A. Rodriguez, C. J. Gore, J. Stray-Gundersen, et al. Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1977 - R1984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Haentjens, A. Van Meerhaeghe, A. Moscariello, S. De Weerdt, K. Poppe, A. Dupont, and B. Velkeniers The Impact of Continuous Positive Airway Pressure on Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome: Evidence From a Meta-analysis of Placebo-Controlled Randomized Trials Arch Intern Med, April 23, 2007; 167(8): 757 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Smith and C. F. Pacchia Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Sleep apnoea and hypertension: role of chemoreflexes in humans Exp Physiol, January 1, 2007; 92(1): 45 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Foster, M. J. Poulin, and P. J. Hanly Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea Exp Physiol, January 1, 2007; 92(1): 51 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Prabhakar, T. E. Dick, J. Nanduri, and G. K. Kumar Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia Exp Physiol, January 1, 2007; 92(1): 39 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Dick, Y.-H. Hsieh, N. Wang, and N. Prabhakar Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat Exp Physiol, January 1, 2007; 92(1): 87 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Kumar, V. Rai, S. D. Sharma, D. P. Ramakrishnan, Y.-J. Peng, D. Souvannakitti, and N. R. Prabhakar Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress J. Physiol., August 15, 2006; 575(1): 229 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Monahan, U. A. Leuenberger, and C. A. Ray Effect of repetitive hypoxic apnoeas on baroreflex function in humans J. Physiol., July 15, 2006; 574(2): 605 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yun, P. Y. Lee, and A. N. Gerber Integrating systems biology and medical imaging: understanding disease distribution in the lung model. Am. J. Roentgenol., April 1, 2006; 186(4): 925 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J Madden and S. F Morrison Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats J. Physiol., July 15, 2005; 566(2): 559 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishimura Reply Nephrol. Dial. Transplant., May 1, 2005; 20(5): 1011 - 1012. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
