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1 Biomedical Sciences, University of Missouri, Columbia, MO, USA
* To whom correspondence should be addressed. E-mail: priorb{at}missouri.edu.
The objectives of this study were to assess the time course of enlargement and gene expression of a collateral vessel that enlarges following occlusion of the femoral artery and to relate these responses to the increases in collateral dependent blood flow to the calf muscles in vivo. We employed exercise training to stimulate collateral vessel development. Rats were exercise trained or kept sedentary for various times of up to 25 days post bilateral occlusion (n=~9/time point). Collateral blood flow to the calf muscles, determined with microspheres, increased modestly over the first few days to ~40 ml/min/100 g in sedentary animals; the increase continued over time to ~80 ml/min/100 g in the trained animals. Diameters of the isolated collateral vessels increased progressively over time, whereas an increased vessel compliance observed at low pressures was similar across time. These responses were greater in the trained animals. The time-course of upregulation of VEGF and PlGF, and particularly eNOS and Flt-1, mRNAs in the isolated collateral vessel implicates these factors as integral to the arteriogenic process. Collateral vessel enlargement and increased compliance at low pressures contribute to the enlarged circuit available for collateral blood flow. However, modulation of the functioning collateral vessel diameter, by smooth muscle tone, must occur to account for the observed increases in collateral blood flow measured in vivo.
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