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1 Cardiovascular Biophysics Laboratory, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA
* To whom correspondence should be addressed. E-mail: sjk{at}wuphys.wustl.edu.
The duration of diastole can be defined in terms of mechanical events. Mechanical Diastolic Duration (MDD) is comprised by the phases of early rapid filling (E-wave), diastasis, and late atrial filling (A-wave). The effect of HR on diastolic duration is predictable from kinematic modeling and known cellular physiology. To determine the dependence of MDD, of each phase and the velocity time integral (VTI) on HR, simultaneous transmitral Doppler flow velocities and ECG were recorded during supine bicycle exercise in healthy volunteers. Durations, peak values and VTI using triangular approximation for E-and A-wave shape were measured. MDD, defined as the interval from the start of the E- to end of the A-wave, was fit as a function of HR by: MDD=BMDD+MLMDD*HR+MIMDD/HR, derivable from first principles. Excellent correlation was observed (r2=0.98). E- and A-wave durations were found to be very nearly independent of HR: 100% increase in HR generated only an 18% decrease in E- and 16% decrease in Awave durations. VTI was similarly very nearly independent of HR. Diastasis duration closely tracked MDD as a function of HR. We conclude that the elimination of diastasis and merging of E- and A-waves of nearly fixed durations primarily govern changes in MDD. These observations support the perspective that E- and A-wave durations are primarily governed by the rules of mechanical oscillation that are minimally HR dependent.
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