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Am J Physiol Heart Circ Physiol (October 18, 2001). doi:10.1152/ajpheart.00411.2001
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Articles in PresS, published online ahead of print October 17, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00411.2001
Submitted on May 17, 2001
Accepted on October 9, 2001

Modulatory role of a constitutively active population of {alpha}1D-adrenoceptors in conductance arteries

Khalid Ziani1, Regina Gisbert1, Maria Antonia Noguera1, Maria Dolores Ivorra1, and Pilar D'Ocon1*

1 Farmacologia, Facultad de Farmacia, Burjassot, Valencia, Spain

* To whom correspondence should be addressed. E-mail: m.pilar.docon{at}uv.es.

A constitutively active population of {alpha}1D-adrenoceptors in iliac and proximal, distal and small mesenteric rat arteries was studied. The increase in the resting tone (IRT) that evidences it was observed only in iliac and proximal mesenteric and was inhibited by prazosin (pIC50= 9.57), 5-methylurapidil ( pIC50 = 7.61) and BMY 7378 (pIC50 = 8.77). Chloroethylchlonidine 100 µmolL-1 did not affect IRT, but when added before the other antagonists it blocked their effect. The potency shown by BMY 7378 confirms the {alpha}1D subtype as responsible for IRT. BMY 7378 displayed greater inhibition of adrenergic responses in iliac (pIC50 = 7.57 ± 0.11) and proximal (pIC50 = 8.05 ± 0.2) than in distal (pIC50 = 6.94 ± 0.13) or small mesenteric (pIC50 = 6.30 ± 0.14), which confirms the functional role of {alpha}1D-adrenoceptor in iliac and proximal mesenteric. This subtype prevents abrupt changes in iliac and proximal mesenteric caliber when the agonist disappears, and this modulatory role is evidenced by the slower decay in the response to noradrenaline after removal.




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