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Am J Physiol Heart Circ Physiol (January 23, 2003). doi:10.1152/ajpheart.00416.2002
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Submitted on May 15, 2002
Accepted on January 10, 2003

Tonin in rat heart with experimental hypertrophy

Julio C. Borges1, Jose A. Silva2, Maria A. Gomes3, Eliane S. Lomez1, Katia M. Leite1, Ronaldo C. Araujo4, Michael Bader5, Joao B. Pesquero2, and Jorge L. Pesquero1*

1 Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
2 Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
3 Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
4 University of Mogi das Cruzes, Mogi das Cruzes, Sao Paulo, Brazil
5 Max-Delbruck Center for Molecular Medicine, Berlin, Germany

* To whom correspondence should be addressed. E-mail: jlpesq{at}icb.ufmg.br.

The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE) and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol during seven days (5 mg/kg/day, sc). For untreated animals, the levels of tonin specific activity in the atrium were 2.6- and 5.5-fold higher than that of left and right ventricles respectively. After treatment the levels of tonin specific activity increased 2-fold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures and ACE expression levels did not change by treatment. Angiotensinogen expression was detected in the left ventricle at very low levels when compared to the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role on the process of heart hypertrophy in the rat.




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