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Am J Physiol Heart Circ Physiol (November 29, 2001). doi:10.1152/ajpheart.00431.2001
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Articles in PresS, published online ahead of print November 29, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00431.2001
Submitted on May 21, 2001
Accepted on November 19, 2001

Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Jose R Fioretto1*, Susana S Querioz1, Carlos R Padovani2, Luiz S Matsubara3, Katashi Okoshi3, and Beatriz B Matsubara3

1 Department of Pediatrics, Sao Paulo State University, Botucatu Medical School, Botucatu, Brazil
2 Department of Biostatistics, Sao Paulo State University, Botucatu Medical School, Botucatu, Brazil
3 Department of Internal Medicine, Sao Paulo State University, Botucatu Medical School, Botucatu, Brazil

* To whom correspondence should be addressed. E-mail: fioretto{at}fmb.unesp.br.

The effects of protein-calorie malnutrition (PCM) on heart structure and function are not completely understood. We studied heart morphometric, functional, and biochemical characteristics in undernourished young Wistar rats. They were submitted to PCM from birth (undernourished group, UG). After 10 weeks, left ventricle function was studied in Langendorff preparation. The results were compared with age-matched rats fed ad libitum (control group, CG). The undernourished rats achieved 47% body weight and 44% left ventricular weight (LVW) of CG. Heart and body weights decreased proportionally. LVW/ventricular volume ratio was smaller and myocardial hydroxyproline concentration higher in UG. Left ventricular systolic function was not affected by the PCM protocol. The myocardial stiffness constant was greater in UG, while the end-diastolic pressure-volume relationship was not altered. In conclusion, the heart is not spared from the adverse effects of PCM. There is a geometric alteration in left ventricle with preserved ventricular compliance despite the increased passive myocardial stiffness. The systolic function is preserved.






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