| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print October 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00449.2002
Submitted on May 28, 2002
Accepted on October 22, 2002
1 Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USA
* To whom correspondence should be addressed. E-mail: robert-tomanek{at}uiowa.edu.
Previous studies from our laboratory and those of others have shown thryoxine to be a stimulator of coronary microvascular growth. The present study tested the hypothesis that diiodothyropropionic acid (DITPA), a thyroid hormone analog with inotropic but not chronotopic characteristics, is angiogenic in the non-ischemic heart. Daily injections, (3.75 mg/kg, s.c.) of DITPA to Sprague Dawley rats affected protein increases in VEGF164, VEGF188, bFGF (FGF-2), angiopoietin-1 and Tie-2 during the first few days of treatment. After 3 weeks of treatment arteriolar length density and the relative number of terminal arterioles (<10µm diameter) increased in the left ventricle as determined by image analysis of perfuse-fixed hearts. These findings occurred in hearts which did not undergo changes in mass, nor in increases in capillary length density. We conclude that DITPA, which is known to improve ventricular function after infarction, is angiogenic in normal, non-ischemic hearts.
This article has been cited by other articles:
|
|
 |
|
  Y. Liu, D. Wang, R. A. Redetzke, B. A. Sherer, and A. M. Gerdes Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1551 - H1557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Schlenker, M. Hora, Y. Liu, R. A. Redetzke, E. Morkin, and A. M. Gerdes Effects of thyroidectomy, T4, and DITPA replacement on brain blood vessel density in adult rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1504 - R1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. I. Khalife, Y.-D. Tang, J. A. Kuzman, T. A. Thomas, B. E. Anderson, S. Said, P. Tille, E. H. Schlenker, and A. M. Gerdes Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2409 - H2415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Kuzman, T. A. Thomas, K. A. Vogelsang, S. Said, B. E. Anderson, and A. M. Gerdes Effects of induced hyperthyroidism in normal and cardiomyopathic hamsters J Appl Physiol, October 1, 2005; 99(4): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Lamping, W. Zheng, D. Xing, L. P. Christensen, J. Martins, and R. J. Tomanek Bradycardia Stimulates Vascular Growth During Gradual Coronary Occlusion Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2122 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lei, R. Zhou, W. Zheng, L. P. Christensen, R. M. Weiss, and R. J. Tomanek Bradycardia Induces Angiogenesis, Increases Coronary Reserve, and Preserves Function of the Postinfarcted Heart Circulation, August 17, 2004; 110(7): 796 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, R. M. Weiss, X. Wang, R. Zhou, A. M. Arlen, L. Lei, E. Lazartigues, and R. J. Tomanek DITPA stimulates arteriolar growth and modifies myocardial postinfarction remodeling Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1994 - H2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Lamping, L. P. Christensen, and R. J. Tomanek Estrogen therapy induces collateral and microvascular remodeling Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2039 - H2044. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
