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Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00462.2002
Submitted on June 6, 2002
Accepted on July 15, 2002
1 Department of Surgery, Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, N.C., USA; Center for Emerging Cardiovascular Technologies, Duke University Medical Center, Durham, N.C., USA
2 Center for Emerging Cardiovascular Technologies, Duke University Medical Center, Durham, N.C., USA
3 Department of Surgery, Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, N.C., USA
* To whom correspondence should be addressed. E-mail: apasipou{at}duke.edu.
By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in awake dogs at control (CL: n=16) and under surgically induced subacute (2-5 weeks) RV pressure overload (PO: n=6), volume overload (VO: n=7), and ischemia (IS: n=6) were analyzed. The conventional exponential model detected no changes from CL in the passive filling pressure-volume (Ppf-V) relations. The new sigmoidal model revealed significant quantifiable changes in Ppf-V relations. Maximum RV myocardial compliance (MCmax), attained during early filling, is reduced from control in pressure overload (p=0.0016), while filling pressure at maximum compliance (PMCmax) is increased (p=0.0001). End-diastolic RV myocardial compliance increases significantly in volume overload (p=0.0131), while end-diastolic pressure is unchanged. In ischemia, MCmax is decreased (p=0.0102), with no change in PMCmax. We conclude that the sigmoidal model quantifies important changes in RV diastolic function in awake dog models of PO, VO, and IS.
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