AJP - Heart AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (July 24, 2003). doi:10.1152/ajpheart.00474.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/5/H1976    most recent
00474.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Naumova, A. V.
Right arrow Articles by Chacko, V. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Naumova, A. V.
Right arrow Articles by Chacko, V. P.
Submitted on May 22, 2003
Accepted on July 10, 2003

Regulation of Murine Myocardial Energy Metabolism during Adrenegic Stress Studied by In Vivo Phosphorus-31 NMR Spectroscopy

A. V. Naumova1, R. G. Weiss2, and V. P. Chacko1*

1 Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
2 Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: chacko{at}mri.jhu.edu.

Image-guided, spatially localized 31P magnetic resonance spectroscopy (MRS) was used to study in vivo murine cardiac metabolism under resting and dobutamine-induced stress conditions. Intravenous dobutamine infusion (24 µg/min/kg body weight) increased the mean heart rate by ~39% from 482±/-46/min at baseline to 669±/-77/min in adult mice. The myocardial phosphocreatine to adenosine triphosphate (PCr/ATP) ratio remained unchanged at 2.1±/-0.5 during dobutamine stress, as compared to baseline conditions. Therefore, we conclude that a significant increase in heart rate does not result in a decline in the in vivo murine cardiac PCr/ATP ratio. These observations in very small mammals, viz., mice, at extremely high heart rates are consistent with studies in large animals demonstrating that global levels of high-energy phosphate metabolites do not regulate in vivo myocardial metabolism during physiologically relevant increases in cardiac work.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Gupta, V. P. Chacko, and R. G. Weiss
Abnormal energetics and ATP depletion in pressure-overload mouse hearts: in vivo high-energy phosphate concentration measures by noninvasive magnetic resonance
Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H59 - H64.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Ojha, S. Roy, J. Radtke, O. Simonetti, S. Gnyawali, J. L. Zweier, P. Kuppusamy, and C. K. Sen
Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2435 - H2443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Y. Maslov, V. P. Chacko, M. Stuber, A. L. Moens, D. A. Kass, H. C. Champion, and R. G. Weiss
Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H387 - H391.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. C. Kreissl, H.-M. Wu, D. B. Stout, W. Ladno, T. H. Schindler, X. Zhang, J. O. Prior, M. L. Prins, A. F. Chatziioannou, S.-C. Huang, et al.
Noninvasive Measurement of Cardiovascular Function in Mice with High-Temporal-Resolution Small-Animal PET
J. Nucl. Med., June 1, 2006; 47(6): 974 - 980.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.