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Articles in PresS, published online ahead of print January 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00491.2001
Submitted on June 5, 2001
Accepted on January 25, 2002
1 Biomedical Engineering and Mechanics, Delft University of Technology, Delft, Netherlands; Medical Physics; Cardiovascular Research Institute Amsterdam, University of Amsterdam, Amsterdam, Netherlands
2 Biomedical Engineering and Mechanics, Delft University of Technology, Delft, Netherlands
3 Medical Physics; Cardiovascular Research Institute Amsterdam, University of Amsterdam, Amsterdam, Netherlands
* To whom correspondence should be addressed. E-mail: A.Cornelissen{at}AMC.UVA.NL.
Myogenic response, flow-dependent dilation and direct metabolic control are important mechanisms to control coronary flow. A model is developed to study how these control mechanisms interact at different locations in the arteriolar tree and to evaluate their contribution to autoregulatory and metabolic flow control. The model consists of 10 resistance compartments in series, each representing parallel vessel units, with their diameters determined by tone depending on either: flow and pressure (TRFflow*Tonemyo) or directly on metabolic factors (Tonemeta). The pressure-Tonemyo and flow-TRFflow relations depend on the vessel size obtained from interpolation of data on isolated vessels. Flow-dependent dilation diminishes autoregulatory properties in comparison with pressure-flow lines obtained from vessels solely influenced by Tonemyo. Applying Tonemeta to the four distal compartments, the autoregulatory properties are restored and tone is equally distributed over the compartments. Also metabolic control and blockage of NO are simulated. We conclude that a balance is required between the flow-dependent properties upstream and the constrictive metabolic properties downstream. Myogenic response contributes significantly to flow regulation.
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