| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print January 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00491.2001
Submitted on June 5, 2001
Accepted on January 25, 2002
1 Biomedical Engineering and Mechanics, Delft University of Technology, Delft, Netherlands; Medical Physics; Cardiovascular Research Institute Amsterdam, University of Amsterdam, Amsterdam, Netherlands
2 Biomedical Engineering and Mechanics, Delft University of Technology, Delft, Netherlands
3 Medical Physics; Cardiovascular Research Institute Amsterdam, University of Amsterdam, Amsterdam, Netherlands
* To whom correspondence should be addressed. E-mail: A.Cornelissen{at}AMC.UVA.NL.
Myogenic response, flow-dependent dilation and direct metabolic control are important mechanisms to control coronary flow. A model is developed to study how these control mechanisms interact at different locations in the arteriolar tree and to evaluate their contribution to autoregulatory and metabolic flow control. The model consists of 10 resistance compartments in series, each representing parallel vessel units, with their diameters determined by tone depending on either: flow and pressure (TRFflow*Tonemyo) or directly on metabolic factors (Tonemeta). The pressure-Tonemyo and flow-TRFflow relations depend on the vessel size obtained from interpolation of data on isolated vessels. Flow-dependent dilation diminishes autoregulatory properties in comparison with pressure-flow lines obtained from vessels solely influenced by Tonemyo. Applying Tonemeta to the four distal compartments, the autoregulatory properties are restored and tone is equally distributed over the compartments. Also metabolic control and blockage of NO are simulated. We conclude that a balance is required between the flow-dependent properties upstream and the constrictive metabolic properties downstream. Myogenic response contributes significantly to flow regulation.
This article has been cited by other articles:
|
|
 |
|
  D. Xiao, S. Yang, and L. Zhang Prenatal Cocaine Exposure Causes Sex-Dependent Impairment in the Myogenic Reactivity of Coronary Arteries in Adult Offspring Hypertension, November 1, 2009; 54(5): 1123 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Carlson, J. C. Arciero, and T. W. Secomb Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1572 - H1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Spaan, C. Kolyva, J. van den Wijngaard, R. ter Wee, P. van Horssen, J. Piek, and M. Siebes Coronary structure and perfusion in health and disease Phil Trans R Soc A, September 13, 2008; 366(1878): 3137 - 3153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kleinstreuer, T. David, M. J. Plank, and Z. Endre Dynamic myogenic autoregulation in the rat kidney: a whole-organ model Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1453 - F1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gautier, J.-M. Hyvelin, V. de Crescenzo, V. Eder, and P. Bonnet Heterogeneous Kv1 function and expression in coronary myocytes from right and left ventricles in rats Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H475 - H482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev, October 1, 2006; 86(4): 1263 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Kern, A. Lerman, J.-W. Bech, B. De Bruyne, E. Eeckhout, W. F. Fearon, S. T. Higano, M. J. Lim, M. Meuwissen, J. J. Piek, et al. Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology Circulation, September 19, 2006; 114(12): 1321 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Rogers, T. Kiyooka, and W. M. Chilian Is there a need for another model on the pulsatile nature of coronary blood flow? Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1034 - H1035. [Full Text] [PDF]
|
|
|
|
|
|
N. Mittal, Y. Zhou, C. Linares, S. Ung, B. Kaimovitz, S. Molloi, and G. S. Kassab Analysis of blood flow in the entire coronary arterial tree Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H439 - H446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pipp, S. Boehm, W.-J. Cai, F. Adili, B. Ziegler, G. Karanovic, R. Ritter, J. Balzer, C. Scheler, W. Schaper, et al. Elevated Fluid Shear Stress Enhances Postocclusive Collateral Artery Growth and Gene Expression in the Pig Hind Limb Arterioscler Thromb Vasc Biol, September 1, 2004; 24(9): 1664 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Zulliger, A. Rachev, and N. Stergiopulos A constitutive formulation of arterial mechanics including vascular smooth muscle tone Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1335 - H1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Korzick, M. H. Laughlin, and D. K. Bowles Alterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries J Appl Physiol, April 1, 2004; 96(4): 1425 - 1432. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
