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Am J Physiol Heart Circ Physiol (September 5, 2002). doi:10.1152/ajpheart.00515.2002
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Articles in PresS, published online ahead of print September 5, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00515.2002
Submitted on June 21, 2002
Accepted on August 29, 2002

Role of AT2 Receptor in the Brain in Regulation of Blood Pressure and Water Intake

Zhen Li1, Masaru Iwai1, Lan Wu1, Tetsuya Shiuchi1, Toyohisa Jinno2, Tai-Xing Cui1, and Masatsugu Horiuchi1*

1 Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Ehime, Japan
2 Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Ehime, Japan; Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Osaka, Japan

* To whom correspondence should be addressed. E-mail: horiuchi{at}m.ehime-u.ac.jp.

The effects of intracerebroventricular (ICV) injection of angiotensin II (Ang II) on blood pressure and water intake were examined using Ang II receptor-deficient mice. ICV injection of Ang II increased systolic blood pressure in a dose-dependent manner in wild type (WT) and AT2 receptor null (AT2KO) mice, however, this increase was significantly greater in AT2KO mice than in WT mice. The pressor response to central injection of Ang II in WT mice was inhibited by ICV pre-injection of a selective AT1 receptor blocker, valsartan, but exaggerated by an AT2 receptor blocker, PD123319. ICV injection of Ang II also increased water intake. It was partly but significantly suppressed both in AT2KO and AT1aKO mice. Water intake in AT2/AT1aKO mice did not respond to ICV injection of Ang II. Both valsartan and PD123319 partly inhibited water intake in WT mice. These results indicate an antagonistic action between central AT1a and AT2 receptors in the regulation of blood pressure, but they act synergistically in the regulation of water intake induced by Ang II.




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