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Am J Physiol Heart Circ Physiol (November 14, 2002). doi:10.1152/ajpheart.00529.2002
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Articles in PresS, published online ahead of print November 14, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00529.2002
Submitted on June 25, 2002
Accepted on November 11, 2002

Arterial Distensibility: Acute Changes Following Dynamic Exercise in Normal Subjects

Katerina K Naka1, Ann C Tweddel2, Dimitris Parthimos3, Andrew H Henderson1, Jonathan Goodfellow1*, and Michael P Frenneaux1

1 Department of Cardiology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, United Kingdom
2 Department of Nuclear Cardiology, University Hospital of Wales, Cardiff, United Kingdom
3 Department of Diagnostic Radiology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, United Kingdom

* To whom correspondence should be addressed. E-mail: goodfellowj{at}cardiff.ac.uk.

The time course of acute changes in large artery distensibility immediately and for 60 minutes following maximum treadmill exercise in normal subjects was characterised by simultaneously measuring upper and lower limb pulse wave velocity (PWV). A new oscillometric technique was used which has proved sensitive to changes in distensibility induced by acute changes in vascular tone independently of blood pressure. The observed changes in PWV are attributable to changes in vascular tone corresponding to recovery from a systemic net constrictor response and a local net dilator response to exercise with persisting post-exercise vasodilatation. They are inadequately explained by associated changes in blood pressure, and cannot be attributed to changes in heart rate or viscosity. Modelled as a system of n coupled linear differential equations, the minimum (and adequate) order required to reproduce these patterns was n = 1 for the upper and n = 2 for the exercising lower limb. The economy of the solution suggests entrainment among the multiple interactive mechanisms governing vasomotor control.




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