| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
2 Department of Chemistry, University of Arizona, Tucson, AZ, USA
3 Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
4 Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
5 Division of Neurology, Duke University Medical Center, Durham, NC, USA
6 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: kmiranda{at}email.arizona.edu.
Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nitroxyl (HNO), the one electron reduced product of NO, has recently been shown to have unique and potentially beneficial pharmacological properties. HNO and NO often induce discrete biological responses, providing an interesting redox system. This review discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo.
This article has been cited by other articles:
|
|
 |
|
  N. Paolocci and D. A. Wink The shy Angeli and his elusive creature: the HNO route to vasodilation Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1217 - H1220. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Dai, Y. Tian, C. G. Tocchetti, T. Katori, A. M. Murphy, D. A. Kass, N. Paolocci, and W. D. Gao Nitroxyl increases force development in rat cardiac muscle J. Physiol., May 1, 2007; 580(3): 951 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Manukhina, H. F. Downey, and R. T. Mallet Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Experimental Biology and Medicine, April 1, 2006; 231(4): 343 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Katori, D. B. Hoover, J. L. Ardell, R. H. Helm, D. F. Belardi, C. G. Tocchetti, P. R. Forfia, D. A. Kass, and N. Paolocci Calcitonin Gene-Related Peptide In Vivo Positive Inotropy Is Attributable to Regional Sympatho-Stimulation and Is Blunted in Congestive Heart Failure Circ. Res., February 4, 2005; 96(2): 234 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kalyanaraman and D. D. Gutterman Prologue: Vascular effects of free radicals Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2253 - H2254. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
