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Am J Physiol Heart Circ Physiol (November 14, 2002). doi:10.1152/ajpheart.00532.2002
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Articles in PresS, published online ahead of print November 14, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00532.2002
Submitted on June 26, 2002
Accepted on November 6, 2002

Noninvasive Identification of the Total Peripheral Resistance Baroreflex

Ramakrishna Mukkamala*, Karin Toska, and Richard J. Cohen

* To whom correspondence should be addressed. E-mail: rama{at}egr.msu.edu.

We propose two identification algorithms for quantitating the total peripheral resistance (TPR) baroreflex, an important contributor to short-term arterial blood pressure (ABP) regulation. Each algorithm analyzes beat-to-beat fluctuations in ABP and cardiac output, which may both be obtained noninvasively in humans. For a theoretical evaluation, we applied both algorithms to a realistic cardiovascular model. The results were contrasting with only one of the algorithms proving to be reliable. This algorithm was able to track changes in the static gains of both the arterial and cardiopulmonary TPR baroreflex. We then applied both algorithms to a preliminary set of human data and obtained contrasting results much like those obtained from the cardiovascular model, thereby making the theoretical evaluation results more meaningful. This study suggests that, with experimental testing, the reliable identification algorithm may provide a powerful, noninvasive means for quantitating the TPR baroreflex. This study also provides an example of the role that models can play in the development and initial evaluation of algorithms aimed at quantitating important physiologic mechanisms.




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