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Articles in PresS, published online ahead of print October 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00540.2002
Submitted on June 28, 2002
Accepted on October 3, 2002
* To whom correspondence should be addressed. E-mail: finkk{at}uni-bonn.de.
Knowledge of developmental changes of cardiovascular parameters in a genetic background mouse strain is important for understanding phenotypic changes in transgenic or knockout mouse models for heart disease. We studied arterial blood pressure and myocardial contractility in mice of the common background strain C57BL/6, aged 21 (P21) to 580 days (P580). Heart rate increased during maturation from 396 bpm at P21 to 551 bpm at P50, mean arterial blood pressure increased in parallel from 86 to 110 mmHg and remained constant afterwards. Echocardiographically determined left ventricular myocardial wall dimensions (R=0.79; p<0.0001) and left ventricular mass calculated using the area-length algorithm correlated strongly with histomorphometrical measurements (R=0.93; p<0.001). Sarcomere shortening records from isolated ventricular myocytes used as a measure for myocardial contractility revealed a negative shortening-frequency relation under 2 Hz pacing frequency and a positive relation above 2 Hz. Shortening amplitudes recorded from P21 myocytes were smaller and the shortening-frequency relation was less steep than in adult. A stimulation pause was followed by a negative "staircase" at
6 Hz pacing frequency and a positive "staircase" at 
6 Hz. P21 myocytes developed positive "staircases" at 8 and 10 Hz, adult myocytes also at 6 Hz. Blood pressure increase during maturation until P50 may originate from increasing single cardiomyocyte contractility.
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