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* To whom correspondence should be addressed. E-mail: jacob{at}bichat.inserm.fr.
Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred BN rat differs significantly from the outbred LE and the inbred LOU rats with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as factors which may modulate these parameters (Insulin Growth Factor-I [IGF-I], Transforming Growth Factor beta-1 [TGF-
1] and Matrix Metalloproteinase-2 [MMP-2]) in seven inbred rat strains, including BN and LOU. We also investigated whether IEL ruptures occur in strains other than the BN. We showed that LOU, LE, BN and F344 rats were significantly different for aortic elastin content and elastin/collagen ratio whereas LE, LEW, WAG and WF were similar for these parameters. BN and F344 had the lowest values. BN was the only strain to present numerous IEL ruptures whereas F344, LE and WF presented a few and the other strains, none. In addition, IGF-I and TGF-1 levels in plasma and aorta differed significantly between strains suggesting genetic control of their production. Since inbred rat strains provide interesting models for Quantitative Trait Locus (QTL) analysis, our results concerning elastin, collagen, IEL ruptures and cytokines may provide a basis for the search for candidate genes involved in the control of these phenotypes.
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