AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (August 29, 2002). doi:10.1152/ajpheart.00549.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/6/H2288    most recent
00549.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schubert, R.
Right arrow Articles by Krien, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schubert, R.
Right arrow Articles by Krien, U.

Articles in PresS, published online ahead of print August 29, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00549.2002
Submitted on July 2, 2002
Accepted on August 19, 2002

Rho-kinase inhibition partly weakens myogenic reactivityin rat small arteries by changing calcium sensitivity

Rudolf Schubert1*, Vjatscheslav U Kalentchuk2, and Ulrike Krien1

1 Institute of Physiology, University of Rostock, Rostock, Germany
2 Department of Pathophysiology, Moscow State University, Moscow, Russian Federation

* To whom correspondence should be addressed. E-mail: rudolf.schubert{at}medizin.uni-rostock.de.

The hypothesis that Rho-kinase is involved in myogenic reactivity was investigated in pressurized rat tail small arteries using videomicroscopic diameter determination and calcium fluorimetry. The potent Rho-kinase inhibitor, Y-27632, reversibly increased vessel diameter at 80 mmHg without changing the intracellular calcium concentration ([Ca]i) shifting the relationship between diameter change and [Ca]i to higher calcium levels. Neither endothelium removal nor inhibition of neural transmission affected the Y-27632-induced effect. Y-27632 at 3*10-6 mol l-1 attenuated the myogenic response in the pressure range from 10 to 120 mmHg shifting the relationship between vessel tone and [Ca]i to higher calcium levels. In addition, the Y-27632-induced shift of the relationship between vessel tone and [Ca]i was larger at 80 than at 10 mmHg. These results suggest that smooth muscle cell Rho-kinase in rat tail small arteries 1) is in an active state partly determining the level of the myogenic tone, and 2) alters the strength of the myogenic response by changing calcium sensitivity, probably caused by the pressure-induced activation of the kinase.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
R. P. Johnson, A. F. El-Yazbi, K. Takeya, E. J. Walsh, M. P. Walsh, and W. C. Cole
Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response
J. Physiol., June 1, 2009; 587(11): 2537 - 2553.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. W. Inscho, A. K. Cook, R. C. Webb, and L.-M. Jin
Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter
Am J Physiol Renal Physiol, March 1, 2009; 296(3): F590 - F597.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. W. Inscho
Mysteries of Renal Autoregulation
Hypertension, February 1, 2009; 53(2): 299 - 306.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
E.J. Belin de Chantemele, K. Retailleau, F. Pinaud, E. Vessieres, A. Bocquet, A.L. Guihot, B. Lemaire, V. Domenga, C. Baufreton, L. Loufrani, et al.
Notch3 Is a Major Regulator of Vascular Tone in Cerebral and Tail Resistance Arteries
Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2216 - 2224.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Schubert, D. Lidington, and S.-S. Bolz
The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction
Cardiovasc Res, January 1, 2008; 77(1): 8 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Bussemaker, F. Pistrosch, S. Forster, K. Herbrig, P. Gross, J. Passauer, and R. P. Brandes
Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H541 - H547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. Hill and M. J. Davis
Coupling a change in intraluminal pressure to vascular smooth muscle depolarization: still stretching for an explanation
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2570 - H2572.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Ito, Y. P. R. Jarajapu, M. B Grant, and H. J Knot
Characteristics of myogenic tone in the rat ophthalmic artery
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H360 - H368.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Dubroca, X. Loyer, K. Retailleau, G. Loirand, P. Pacaud, O. Feron, J.-L. Balligand, B. I. Levy, C. Heymes, and D. Henrion
RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries
Cardiovasc Res, January 1, 2007; 73(1): 190 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Loirand, P. Guerin, and P. Pacaud
Rho Kinases in Cardiovascular Physiology and Pathophysiology
Circ. Res., February 17, 2006; 98(3): 322 - 334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. A. Martinez-Lemus, T. Crow, M. J. Davis, and G. A. Meininger
{alpha}v{beta}3- and {alpha}5{beta}1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H322 - H329.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. I. Gokina, K. M. Park, K. McElroy-Yaggy, and G. Osol
Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity
J Appl Physiol, May 1, 2005; 98(5): 1940 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Dubroca, D. You, B. I. Levy, L. Loufrani, and D. Henrion
Involvement of RhoA/Rho Kinase Pathway in Myogenic Tone in the Rabbit Facial Vein
Hypertension, May 1, 2005; 45(5): 974 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Loirand, M. Rolli-Derkinderen, and P. Pacaud
RhoA and resistance artery remodeling
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1051 - H1056.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Heaps, J. L. Parker, M. Sturek, and D. K. Bowles
Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries
J Appl Physiol, July 1, 2004; 97(1): 310 - 316.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. H. Korzick, M. H. Laughlin, and D. K. Bowles
Alterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries
J Appl Physiol, April 1, 2004; 96(4): 1425 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Hosaka, R. Mizuno, and T. Ohhashi
Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2015 - H2025.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Osol and J. Brayden
Prologue: vascular myogenic mechanisms
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2157 - H2159.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.