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Am J Physiol Heart Circ Physiol (July 8, 2004). doi:10.1152/ajpheart.00568.2004
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Submitted on June 10, 2004
Accepted on July 1, 2004

Novel Targets of Angiotensin II Regulation in Mouse Heart Identified by Serial Analysis of Gene Expression

Faina Schwartz1*, Arvi Duka2, Irena Duka2, Jing Cui2, and Haralambos Gavras2

1 Genetics Program, Boston University School of Medicine, Boston, MA, USA
2 Department of Medicine, Hypertension and Atherosclerosis Section, Boston University School of Medicine, Boston, MA, USA

* To whom correspondence should be addressed. E-mail: fschw{at}bu.edu.

Although the central role of angiotensin II (AngII) in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is incompletely understood. Using serial analysis of gene expression (SAGE) to assess global transcriptional changes in the heart of mice following continuous 7-day AngII administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered a number of novel AngII targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The SAGE approach to assess the role of AngII presented in this report provides new venues for inquiries into AngII-mediated cardiac function.




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