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Am J Physiol Heart Circ Physiol (October 9, 2003). doi:10.1152/ajpheart.00572.2003
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Submitted on June 18, 2003
Accepted on October 5, 2003

DO P2X PURINERGIC RECEPTORS REGULATE SKELETAL MUSCLE BLOOD FLOW DURING EXERCISE?

John B. Buckwalter1*, Jessica C. Taylor1, Jason J. Hamann1, and Philip S. Clifford1

1 Departments of Anesthesiology and Physiology, Medical College of Wisconsin and VA Medical Center, Milwaukee, WI, USA

* To whom correspondence should be addressed. E-mail: jbuckwal{at}mcw.edu.

Although there is evidence that sympathetic nerves release ATP as a neurotransmitter to produce vasoconstriction via P2X purinergic receptors, the role of these receptors in the regulation of blood flow to exercising skeletal muscle has yet to be determined. We hypothesized that there is tonic P2X receptor mediated vasoconstriction in exercising skeletal muscle. To test this hypothesis, the effect of P2X receptor blockade on skeletal muscle blood flow was examined in 6 exercising mongrel dogs. P2X receptor antagonism was accomplished with pyridoxal-phosphate-6-azophenyl-2'4'-disulfonic acid (PPADs). The animals were instrumented chronically with flowprobes on the external iliac arteries of both hindlimbs and a catheter in one femoral artery. PPADs (40mg) was infused as a bolus into the femoral artery catheter during steady state exercise at 6 miles/h. Intraarterial infusion of PPADs increased iliac blood flow from 542±55 to 677±69 ml/min (p<0.05) and iliac vascular conductance from 5.17±0.62 to 6.53±0.80 ml/min/mmHg. The PPADs infusion did not affect blood flow in the contralateral iliac artery. These data support the hypothesis that P2X purinergic receptors produce vasoconstriction in exercising skeletal muscle.




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