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1 Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana, USA
* To whom correspondence should be addressed. E-mail: dlefer{at}lsuhsc.edu.
Clinical studies have reported that the incidence and severity of myocardial infarction is significantly greater in diabetics compared to non-diabetics following correction for all other risk factors. The majority of studies investigating the pathophysiology of myocardial ischemia-reperfusion injury have focused on otherwise healthy animals. At present, there is a paucity of experimental investigations on the pathophysiology of heart failure in diabetic animals. We hypothesized that the severity of myocardial reperfusion injury and the development of congestive heart failure would be markedly enhanced in the db/db diabetic mouse. Accordingly, we studied the effects of varying durations of in vivo myocardial ischemia (MI) and reperfusion on the incidence of heart failure in db/db diabetic mice. Non-diabetic and db/db diabetic mice (10 weeks of age) were subjected to 30, 45, or 60 minutes (min.) of left coronary artery occlusion and 28 days of reperfusion. Survival at 24 hours of reperfusion was 100% in non-diabetic mice subjected to 30 min. of MI and 88% in non-diabetic mice subjected to 45 min. of MI. In contrast, survival was 53% in db/db diabetic mice subjected to 30 min. of MI and 44% in db/db mice following 45 min of MI. Prolonged survival in non-diabetic mice was not significantly attenuated compared during the 28 day follow up period with all groups experiencing > 90% survival. Prolonged survival was significantly decreased in db/db mice following both 30 and 45 min. of MI compared to sham MI controls. Furthermore, we observed a significant degree or LV dilatation, cardiac hypertrophy, and cardiac contractile dysfunction in db/db mice subjected to 45 min. of MI and 28 days reperfusion. In non-diabetic mice subjected to 45 min. of MI we failed to observe any changes in LV dimensions or fractional shortening. These studies provide a feasible experimental model system for the investigation of heart failure secondary to acute myocardial infarction in the db/db diabetic mice.
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