This study was aimed to investigate the cardiovascular consequences of oral administration of Cedrelopsis grevei (CG) in normotensive rats. Experiments were designed to investigate haemodynamic parameters in vivo as well as consequences of the treatment on vasoconstriction response to norepinephrine and vasorelaxant response to acetylcholine ex vivo in isolated aorta and small mesenteric arteries (SMA). Treatment of male Wistar rats with 80 mg/kg CG for 4 weeks induced a progressive decrease in systolic blood pressure. In the aorta, CG did not significantly alter the response to norepinephrine despite the participation of extra-endothelial NO-induced hyporeactivity. In the SMA, contraction to norepinephrine was not modified by CG treatment even though it enhanced the participation of endothelial NO. Endothelium-dependent relaxation to acetylcholine was increased both in aorta and SMA from CG-treated rats. In aorta from CG-treated rats, the mechanism involved superoxide dismutase (SOD) and catalase sensitive free radical production. The latter was associated with an enhanced expression of Cu/Zn SOD and endothelial NO synthase. These results suggest that oral administration of CG produces a decrease in blood pressure in normotensive rats. This haemodynamic effect was associated with an enhanced endothelium-dependent relaxation and an induction of Cu/Zn SOD and endothelial NO synthase expressions in the vessel wall. They also show subtle mechanisms that compensate the increased participation of NO to maintain unchanged agonist-induced contractility. These data provide pharmacological basis on the empirical use of CG against cardiovascular diseases.