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1 Health and Kinesiology, University of Texas at Tyler, Tyler, Texas, United States
2 Division of Exercise Physiology, West Virginia Univ Sch Med, Morgantown, West Virginia, United States
3 Veterinary Physiology and Pharmacology, Texas A & M University, College Station, Texas, United States
4 Exercise Physiology, West Virginia University, Morgantown, West Virginia, United States
5 Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, United States
* To whom correspondence should be addressed. E-mail: jdelp{at}hsc.wvu.edu.
Flow-induced vasodilation is attenuated with old age in rat skeletal muscle arterioles. The purpose of this study was to determine whether diminished cyclooxygenase (COX) signaling contributes to the age-induced attenuation of flow-induced vasodilation in gastrocnemius muscle arterioles, and to determine whether, and through which mechanism(s), exercise training restores this deficit in old rats. Three- and 22-month-old Fischer 344 rats were assigned to a sedentary (SED) or exercise-trained (ET) group. First-order arterioles were isolated from the gastrocnemius muscles, cannulated, and pressurized to 70 cm H2O. Diameter changes were determined in response to graded increases in intraluminal flow in the presence and absence of nitric oxide synthase (NOS) inhibition (L-NAME, 10-5 M), COX inhibition (Indomethacin, 10-5 M), or combination NOS (L-NAME, 10-5 M) plus COX (Indomethacin, 10-5 M) inhibition. Aging reduced flow-induced vasodilation in gastrocnemius muscle arterioles. Exercise training restored responsiveness to flow in arterioles of aged rats and enhanced flow-induced vasodilation in arterioles from young rats. L-NAME inhibition of flow-induced vasodilation was greater in arterioles from old rats as compared to those from young rats, and was increased following exercise training in arterioles from both young and old rats. Although the indomethacin-sensitive portion of flow-induced dilation was not altered by age or training, both COX-1mRNA expression and PGI2 production increased with training in arterioles from old rats. These data demonstrate that exercise training restores flow-induced vasodilation in gastrocnemius muscle arterioles from old rats, and enhances flow-induced vasodilation in gastrocnemius muscle arterioles from young rats. In arterioles from both old and young rats, the exercise training-induced enhancement of flow-induced dilation occurs primarily through a NOS mechanism.
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