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Articles in PresS, published online ahead of print August 22, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00593.2002
Submitted on July 12, 2002
Accepted on August 19, 2002
1 Departments of Obstetrics/ Gynecology and Physiology, Univeristy of Alberta, Edmonton, Alberta, Canada; Department of Maternal and Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom
2 Departments of Obstetrics/ Gynecology and Physiology, Univeristy of Alberta, Edmonton, Alberta, Canada
3 Department of Maternal and Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom
* To whom correspondence should be addressed. E-mail: sukrutha{at}ualberta.ca.
The mechanisms underlying vascular adaptations in pregnancy remain to be fully elucidated. One of the contributory mechanisms for reduced vascular tone may be a reduction of myogenic tone. Myogenic tone was assessed as the difference between internal diameter in the presence and absence of external calcium, at different intramural pressure steps (60 mmHg-100 mmHg). Myogenic responses were reduced in resistance-sized mesenteric and main uterine arteries in late pregnant compared to non-pregnant C57BL/6J mice. In vessels from pregnant, but not non-pregnant mice, the myogenic response was enhanced by preincubation with nitric oxide synthase (NOS) inhibitor
(L-NAME), and was further elevated by the gap junction inhibitor, 18-
glycyrrhetinic acid (18- GA) but was unaltered by the cyclooxygenase inhibitor, meclofenamate. Endothelium removal enhanced myogenic tone only in the vessels from pregnant animals, thus confirming the role of the endothelium in modulating myogenic tone in pregnancy. These results suggest that endothelium-derived NO as well as gap junction communications modulate myogenic tone in mouse pregnancy.
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