AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol (August 21, 2003). doi:10.1152/ajpheart.00596.2003
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Submitted on June 24, 2003
Accepted on August 15, 2003

Activation of c-Jun N-Terminal Kinase (JNK) in Rat Heart by Exercise: Effect of Training

M. O. Boluyt1*, A. M. Loyd1, M. H. Roth1, M. J. Randall1, and E. Y. Song1

1 Laboratory of Molecular Kinesiology, Division of Kinesiology, University of Michigan, Ann Arbor, MI, USA

* To whom correspondence should be addressed. E-mail: boluytm{at}umich.edu.

The purpose was to determine whether exercise would activate the c-jun NH2-terminal kinases (JNK) in the heart and whether chronic exercise training would alter the response. Untrained rats were familiarized with the treadmill and assigned to one of 4 groups: low intensity (LI), 10 min, 0%, 15 m.min-1; medium intensity (MI), 10 min, 0%, 33 m.min-1; high intensity (HI), 10 min, 25%, 33 m.min-1; long duration (LD), 30 min, 0%, 15 m.min-1. Another cohort of rats was subjected to a progressive 6 week high intensity training protocol that produced a 12% increase in heart mass. In untrained rats, JNK activity was LI: 1.5 (fold non-run control), MI: 2.0, HI: 2.5, LD: 1.25 immediately after a single bout of exercise. In trained rats, no activation of JNK above baseline was detected after either a 10-min or 1-hour bout of exercise. It is concluded that treadmill exercise activates JNK in the rat heart in an intensity-dependent manner, and that chronic training abrogates the myocardial JNK response to a bout of exercise.




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