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Am J Physiol Heart Circ Physiol (October 10, 2002). doi:10.1152/ajpheart.00608.2002
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Articles in PresS, published online ahead of print October 10, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00608.2002
Submitted on July 16, 2002
Accepted on September 26, 2002

Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model

Kirsten H. Ten Tusscher1* and Alexander V. Panfilov1

1 Department of Theoretical Biology, Utrecht University, Utrecht, -, The Netherlands

* To whom correspondence should be addressed. E-mail: khwjtuss{at}hotmail.com.

Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper we study the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of IK or IK1 current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed towards regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.




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