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Am J Physiol Heart Circ Physiol (April 4, 2002). doi:10.1152/ajpheart.00613.2001
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Articles in PresS, published online ahead of print April 4, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00613.2001
Submitted on July 12, 2001
Accepted on March 28, 2002

Rat Carotid Artery Dilation By PTCA Balloon Catheter Induces Neointima Formation In Presence Of Internal Elastic Lamina Rupture

Ciro Indolfi1*, Daniele Torella2, Carmela Coppola2, Eugenio Stabile2, Giovanni Esposito2, Antonio Curcio1, Alfonso Pisani2, Luigi Cavuto2, Oreste Arcucci2, Manuela Cireddu2, Giancarlo Troncone3, and Massimo Chiariello2

1 Division of Cardiology, Magna Graecia University, Catanzaro, Italy
2 Division of Cardiology, Federico II University, Naples, Italy
3 Department of Pathology, Federico II University, Naples, Italy

* To whom correspondence should be addressed. E-mail: indolfi{at}unicz.it.

Background. The best animal angioplasty model is the porcine model, that is expensive and not available in all labs. The aim of this study was to describe a new rat model of angioplasty. Methods and Results. The balloon injury was induced using a standard PTCA 1.5 mm balloon catheter. The neointimal tissue, arterial dimensions and the injury index were assessed after angioplasty. Ki-67 expression was detected to evaluate cell turnover after balloon angioplasty. In contrast with the standard Clowes model, a significant neointimal formation was detected only in presence of ruptured IEL. A positive correlation between the percentage of ruptured IEL and the amount of neointimal tissue was also demonstrated. The percentage of IEL fracture correlates with the proliferation index, by anti-Ki-67 immunolabeling, 7 and 14 days after the angioplasty. A significant arterial negative remodeling was observed after PTCA balloon dilation. Conclusions. The described inexpensive animal model of restenosis after angioplasty may have great relevance to better understand the mechanisms and to assess new therapeutical strategies for this phenomenon.




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