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Articles in PresS, published online ahead of print February 14, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00625.2001
Submitted on July 18, 2001
Accepted on February 7, 2002
1 Ingenieria Electronica, Universidad Politecnica de Valencia, Valencia, Valencia, Spain
* To whom correspondence should be addressed. E-mail: brodrigu{at}eln.upv.es.
In this work, we have used computer simulations to study the mechanisms of extracellular K+ accumulation during acute ischemia. A modified version of Luo-Rudy phase II action potential (AP) model was used to simulate the electrical behavior of one ventricular myocyte during 14 minutes of simulated ischemia. Our results show that: 1) only the integrated effect of activation of ATP-dependent K+ current (IK(ATP)), an ischemic Na+ inward current and inhibition of Na+/K+ pump activity in the absence of coronary flow replicates the biphasic time course of [K+]o observed during acute ischemia; 2) the time to onset of the plateau phase and the plateau level value are determined by the frequency of stimulation and by the rate of alteration of the three mechanisms. However, acidosis and reduction of extracellular volume produce only a slight anticipation of the plateau phase; 3) cellular K+ loss is mainly due to an increase of K+ efflux via time independent K+ current (IK1) and IK(ATP) rather than to a decrease of K+ influx.
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