| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
* To whom correspondence should be addressed. E-mail: fhe6b{at}virginia.edu.
Cardiac MRI is an accurate noninvasive modality for assessing the structure and function of the murine heart. In addition to conventional imaging, MRI tissue tracking methods can quantify numerous aspects of myocardial mechanics, including intramyocardial displacement, strain, twist, and torsion. In the present study, we developed and applied a novel pulse sequence based on Displacement ENcoding using Stimulated Echoes (DENSE) that achieves multislice coverage, high spatial resolution, and three-dimensional (3D) displacement encoding. Using this technique, myocardial mechanics of C57Bl/6 mice were measured at baseline and one day after experimental myocardial infarction. At baseline, the mean systolic transmural circumferential strain was -0.14 ± 0.02 and the mean systolic radial strain was 0.30 ± 0.05. Changes in circumferential and radial strains from the subepicardium to the subendocardium were detected at baseline (p < 0.05). One day after infarction, significantly reduced 3D displacements and strain were detected in infarcted and noninfarcted myocardium. Infarction also reduced normalized systolic torsion from its baseline value of 1.35 ± 0.27°/mm (R = 0.99) to 0.07 ± 0.54°/mm (R = 0.96, p < 0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in less than one hour of scan time at 4.7 Tesla and may be applied to studies of myocardial mechanics in genetically engineered mice.
This article has been cited by other articles:
|
|
 |
|
  W. D. Gilson, F. H. Epstein, Z. Yang, Y. Xu, K.-M. R. Prasad, M.-C. Toufektsian, V. E. Laubach, and B. A. French Borderzone Contractile Dysfunction Is Transiently Attenuated and Left Ventricular Structural Remodeling Is Markedly Reduced Following Reperfused Myocardial Infarction in Inducible Nitric Oxide Synthase Knockout Mice J. Am. Coll. Cardiol., October 30, 2007; 50(18): 1799 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liu, M. W. Ashford, J. Chen, M. P. Watkins, T. A. Williams, S. A. Wickline, and X. Yu MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2515 - H2521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ashikaga, S. R. Mickelsen, D. B. Ennis, I. Rodriguez, P. Kellman, H. Wen, and E. R. McVeigh Electromechanical analysis of infarct border zone in chronic myocardial infarction Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1099 - H1105. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
