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Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00642.2002
Submitted on July 29, 2002
Accepted on September 11, 2002
1 Department of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria; Department of Physiology, University of Vienna Medical School, Vienna, Austria
2 Department of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria
3 Department of Physiology, University of Vienna Medical School, Vienna, Austria
4 Department of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria; Institute of Medical Physics, University of Vienna Medical School, Vienna, Austria
5 Department of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria; Department of Ophthalmology, University of Vienna Medical School, Vienna, Austria
* To whom correspondence should be addressed. E-mail: guido.dorner{at}univie.ac.at.
We performed a randomized, subject-blinded, placebo and time-controlled, two way cross-over study in 12 healthy male subjects. Placebo or dopamine were administered on two separate study days. After saline infusion dopamine hydrochloride was infused in three consecutive doses [5, 10 and 15 µg/(kg.min)]. Plasma levels of dopamine were determined at each perfusion step. Arterial and venous retinal vessel diameters were measured using a Zeiss Retinal Vessel Analyzer (RVA). Diffuse luminance flicker stimuli of 8 Hertz were applied for 60 sec. Blood pressure and pulse rate were monitored continuously. 8 Hz flicker stimulation increased retinal vessel diameters under basal conditions. The response to 8 Hz flicker light was significantly reduced by dopamine administration. In addition, dopamine slightly but significantly increased retinal vessel diameters. Dopamine hydrochloride significantly increased systolic but not diastolic or mean arterial pressure. The present study indicates that dopamine has a distinct effect on retinal vessel diameters also attenuating the flicker-induced response reactivity of retinal vessels. This implies a role of dopamine in retinal blood flow hemodynamics.
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