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Am J Physiol Heart Circ Physiol (December 5, 2002). doi:10.1152/ajpheart.00644.2002
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Articles in PresS, published online ahead of print December 5, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00644.2002
Submitted on July 23, 2002
Accepted on November 7, 2002

CEREBRAL ARTERY RESPONSES TO PRESSURE AND FLOW IN UREMIC HYPERTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

David I. New1*, Alistair M. Chesser1, Raj C. Thuraisingham1, and Magdi M. Yaqoob1

1 Anthony Raine Research Laboratories, St Bartholomew's Hospital, London, United Kingdom

* To whom correspondence should be addressed. E-mail: dnew{at}sghms.ac.uk.

Impaired cerebral blood flow autoregulation is seen in uremic hypertension, whereas in non-uremic hypertension autoregulation is shifted towards higher perfusion pressure. The cerebral artery constricts in response to a rise in either lumen pressure or flow; we examined these responses in isolated middle cerebral artery segments from uremic Wistar-Kyoto rats (WKYU), normotensive control rats (WKYC) and spontaneously hypertensive rats (SHR). Pressure-induced (myogenic) constriction developed at 100 mmHg, then lumen flow was increased in steps from 0-98 ml/min. Some vessels were studied after endothelium ablation. Myogenic constriction was significantly lower in WKYU (28 ± 2.9%) compared to both WKYC (39 ± 2.5%,P= 0.035) and SHR (40 ± 3.1%,P = 0.018). Flow caused constriction of arteries from all groups in an endothelium-independent manner. The response to flow was similar in WKYU and WKYC, whereas SHR displayed increased constriction compared to WKYU (P < 0.001) and WKYC (P < 0.001). We conclude that cerebral myogenic constriction is decreased in WKYU, whilst flow-induced constriction is enhanced in SHR.




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