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Am J Physiol Heart Circ Physiol (February 6, 2003). doi:10.1152/ajpheart.00646.2002
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Submitted on July 23, 2002
Accepted on February 5, 2003

Ventricular remodeling induced by retinoic acid supplementation in adult rats

Sergio A. Paiva1*, Leonardo A. Zornoff1, Marina P. Okoshi1, Katashi S. Okoshi1, Luiz S. Matsubara1, Beatriz B. Matsubara1, Antonio C. Cicogna1, and Alvaro O. Campana1

1 Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil

* To whom correspondence should be addressed. E-mail: paiva{at}fmb.unesp.br.

Retinoic acid (RA) plays a role in regulating cardiac geometry and function throughout life. The aim of this study was to analyze the cardiac effects of RA in adult rats. Wistar rats were randomly allocated to a control group (C, n=18) receiving standard rat chow and a group treated with RA (RA, n=14) receiving standard rat chow supplemented with RA for 90 days. All animals were evaluated by echocardiography, isolated papillary muscle function and morphological studies. While the RA treated group developed an increase in both left ventricular (LV) mass and LV end-diastolic diameter (LVEDD), the ratio of LV wall thickness/LVEDD remained unchanged when compared with the control group. In the isolated papillary muscle preparation, RA treatment decreased the time to peak developed tension and increased the maximum velocity of isometric relengthening, indicating that systolic and diastolic function were improved. Although RA treatment produced an increase in myocyte cross sectional area, the myocardial collagen volume fraction was similar to controls. Thus, our study demonstrates that small physiological doses of RA induce ventricular remodeling resembling compensated volume-overload hypertrophy in rats.




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