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Articles in PresS, published online ahead of print October 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00653.2002
Submitted on July 25, 2002
Accepted on October 10, 2002
1 Faculte de Medecine, Universite de Picardie Jules Vernes, Amiens, France
2 Research Division, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
* To whom correspondence should be addressed. E-mail: MSlama0508{at}aol.com.
The systematic evaluation of different transthoracic echocardiographic (TTE) methods to determine cardiac output (CO) and the effect of changes in intravascular volume on echocardiographically determined indices of cardiovascular structure on rat has not been documented. Employing 11 Wistar rats, simultaneous echocardiographic and thermodilution measurements of CO were compared at baseline and after blood withdrawal or transfusion at 43 different levels of intravascular volume, and using 10 different echocardiographic approaches. The best correlation (r=0.93; p<0.0001), least bias (-3 ml/min), and best precision (16 ml/min) between thermodilution and echocardiographic methods were obtained at the level of aortic annulus using pulsed Doppler. In conclusion, CO could be accurately assessed in rats using TTE and pulsed Doppler at the level of aortic annulus. This annulus was demonstrated to remain stable; but pulmonary annulus, thoracic aorta, mitral valve, and left ventricular diameters were found to be more modifiable during volumic changes.
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