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Articles in PresS, published online ahead of print December 6, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00666.2001
Submitted on July 27, 2001
Accepted on November 1, 2001
1 Health and Kinesiology, Texas A&M University, College Station, Texas, USA
2 Biomedical Engineering Program, Texas A&M University, College Station, Texas, USA
3 Health and Kinesiology, Texas A&M University, College Station, Texas, USA; Medical Physiology, Texas A&M University, College Station, Texas, USA
* To whom correspondence should be addressed. E-mail: jmd{at}hlkn.tamu.edu.
Exercise capacity and skeletal muscle blood flow during exercise are reduced with advancing age. This reduction in blood flow capacity may be related to increased reactivity of skeletal muscle resistance vessels to vasoconstrictor stimuli. The purpose of this study was to test the hypothesis that aging results in increased vasoconstrictor responses of skeletal muscle resistance arterioles. First order (1A) arterioles (90-220 µm) from gastrocnemius and soleus muscles of young (4 months) and aged (24 months) Fischer rats were isolated, cannulated, and pressurized via hydrostatic reservoirs. Vasoconstriction in response to increases in norepinephrine (NE; 1x10-9 -1x10-4 M) and potassium chloride (KCl; 20-100 mM) concentration and increases in intraluminal pressure (10-130 cm H2O) were evaluated in the absence of flow. Responses to NE and KCl were similar in both soleus and gastrocnemius muscle arterioles from young and aged rats. In contrast, active myogenic responses to changes in intraluminal pressure were diminished in soleus and gastrocnemius arterioles from aged rats. To assess whether alterations in the mechanical properties of resistance arterioles underlie altered myogenic responsiveness, passive diameter responses to pressure and mechanical stiffness were evaluated. There was no effect of age on the structural behavior (passive pressure-diameter relationship) or stiffness of arterioles from either soleus or gastrocnemius muscles. These results suggest that aging does not result in a nonspecific decrease in vasoconstrictor responsiveness of skeletal muscle arterioles. Rather, aging-induced adaptations of vasoreactivity of resistance arterioles appear to be limited to mechanism(s) that are uniquely involved in the signaling of the myogenic response.
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