Submitted on June 11, 2007
Accepted on January 20, 2008
Postural-induced phase shift of respiratory sinus arrhythmia and blood pressure variations - insight from respiratory-phase domain analysis
Kiyoshi Kotani1*, Kiyoshi Takamasu2, Yasuhiko Jimbo3, and Yoshiharu Yamamoto4
1 Human and Engineered Environmental Studies, Frontier Science, Kashiwa, Chiba, Japan
2 Department of precision engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Tokyo, Japan
3 Department of human and engineered environmental studies, Graduate School of Frontier Science, The University of Tokyo, Kashiwa, Chiba, Japan
4 Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
* To whom correspondence should be addressed. E-mail: kotani{at}k.u-tokyo.ac.jp.
The purpose of this study is to evaluate the multiple effects of respiration on cardiovascular variability in different postures, by analyzing respiratory sinus arrhythmia (RSA) and respiratory-related blood pressure (BP) variations for systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) in the respiratory-phase domain. The measurements were conducted for 420 sec on healthy humans in the sitting and standing positions, while the subjects were continuously monitored for heart rate and BP variability, and instantaneous lung volume. The waveforms of RSA and respiratory-related BP variations were extracted as a function of the respiratory phase. In the standing position, the waveforms of the BP variations for SBP, DBP, and PP show their maxima at around the end of expiration (
rad) and the minima at around the end of inspiration (2 rad), while the waveform of RSA is delayed by about 0.35 rad in comparison to the BP waveforms. On the other hand, in the sitting position, the phase of the DBP waveform (1.69 rad) greatly and significantly (P<0.01) differs from that in the standing position (1.20 rad). Also, the phase of PP is delayed and that of RSA is advanced in the sitting position (P<0.01). In particular, the phase shift of the DBP waveform is sufficiently large to alter whole hemodynamic fluctuations, affecting the amplitudes of SBP and PP variations. We conclude that the postural change associated with an altered autonomic balance not only affects the amplitude of RSA but also the phases of RSA and BP variations in a complicated manner and the respiratory-phase domain analysis used in this study is useful for elucidating the dynamical mechanisms of RSA.
