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Am J Physiol Heart Circ Physiol (March 21, 2002). doi:10.1152/ajpheart.00690.2001
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Articles in PresS, published online ahead of print March 21, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00690.2001
Submitted on August 2, 2001
Accepted on March 14, 2002

The myogenic response of rat femoral small arteriesin relation to wall structure and intracellular calcium concentration

Vladimir V. Matchkov1*, Olga S. Tarasova2, Michael J. Mulvany3, and Holger Nilsson1

1 Department of Physiology, University of Aarhus, Aarhus, Denmark
2 Department of Human and Animal Physiology, Moscow State University, Moscow, Russian Federation
3 Department of Pharmacology, University of Aarhus, Aarhus, Denmark

* To whom correspondence should be addressed. E-mail: vvm{at}fi.au.dk.

The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+]i) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5 wk old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102±11 mmHg (n=15) on the ligated side, and 164±6 mmHg (n=15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media/lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+]i was higher in vessels from the ligated hind limb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+]i. Thus myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.




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