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Articles in PresS, published online ahead of print December 12, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00700.2002
Submitted on August 8, 2002
Accepted on December 5, 2002
1 Institut National de la Sante et de la Recherche Medicale U388, Institut Louis Bugnard Centre Hospitalier Universitaire Rangueil, Toulouse, France
* To whom correspondence should be addressed. E-mail: parini{at}toulouse.inserm.fr.
Oxidative stress is one of the factors involved in age-related impairment of cardiac function. In the present study, we investigated the role of the catecholamine-degrading enzymes monoamine oxidases (MAOs) in hydrogen peroxide production in heart of young, adult and old rats. MAO-dependent H2O2 production, measured by a chemiluminescence based assay, increased with age reaching the maximum in 24 month old rats (+ 7.5-fold versus 1 month old rats). The following observations indicate that the age-dependent increase in H2O2 generation was fully related to the MAO-A isoform : 1) at all the ages tested, chemiluminescence production was inhibited by the MAO-A inhibitor clorgyline but not by the MAO-B inhibitor RO-19 6327, 2) enzyme assay, Western-blot and semi-quantitative RT-PCR analysis showed an age-dependent increase in cardiac MAO-A activity, immunodetection and mRNA expression, respectively and 3) MAO-B was undetectable by enzyme assay and Western-blot analysis. These results suggest that MAO-A could be a major source of H2O2 in aging heart.
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